Download PDF by Don R. Baker, Norihari Ken Umetsu: Agrochemical Discovery. Insect, Weed, and Fungal Control
By Don R. Baker, Norihari Ken Umetsu
This publication offers a distinct and present examine the method of discovery within the box of crop defense. As many crops may be able to withstand a number of regulate brokers, it can be crucial to seem for completely new lively forms of compounds. The ebook examines combinatorial chemistry techniques, lengthy utilized in medicinal discovery, to discover new agrochemical forms. functions in enhancing vegetation to supply their very own crop defense or stronger yield and caliber are mentioned. there's additionally a overview of average items, that are discovering elevated use within the improvement of recent capability and kinds of crop regulate agents.
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Extra info for Agrochemical Discovery. Insect, Weed, and Fungal Control
It combines the favorable attributes of rapid breakdown in the environment, low mammalian toxicity both acute and cumulative, and safety toward birds, fish and beneficial insects. It is, therefore, a significant breakthrough for insect control that fills the need for a new mode of action insecticide. We are confident that it will become a valuable tool for die future in crop protection. References 1. , Van Daalen, J. , Naturwissenschaften, 1975, 62, 531-532. 2. S. 3,991,073, 1976. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2000.
Studies by Wing established that the N-caibomethoxy compounds are in fact pro-insecticides and that VI-c (DPX-JW062) is itself only weakly active in the blocking action of sodium channels. However, it appears to be rapidly metabolized by insects to the potent sodium channel blocker Vl-b which is responsible for insecticidal activity (28). We believe that other routes of breakdown either through metabolic detoxification in mammals or microbial breakdown in the environment occur preferentially to provide the wide safety margins we observe.
Progr. Chem. Org. Nat. Prod. 1996, 68, 1-467. 28. Copping, L . ; Hewitt, H. G. Chemistry and mode of action of crop protection agents; Royal Soc. Chemistry: Cambridge, 1998. 29. Duke, S. ; Abbas, H. ; Tanaka, T. In Crop Protection Agents from Nature: Natural products and analogues; Copping, L . ; Royal Society of Chemistry: Cambridge, 1996, pp 82-113. 30. Perry, Ν. ; Foster, L. M . ; Jameson, P. E. N. Z. J. Bot. 1995, 33, 565-568. 31. Lee, D. ; Prisbylla, M. ; Cromartie, T. ; Dagarin, D. ; Howard, S.